Download e-book for iPad: Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic by Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F.

By Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)

ISBN-10: 3540485953

ISBN-13: 9783540485957

ISBN-10: 3540485961

ISBN-13: 9783540485964

Amino Acids Biosynthesis provides the present wisdom of basic in addition to utilized microbiology of amino acids. subject matters mentioned are the amino acid biosynthetic pathways, their genetic and biochemical law, delivery of amino acids and genomics of manufacturing microorganisms. The characterization of the regulate mechanisms of amino acid biosynthesis has published insights into ideas of genetic and biochemical rules, corresponding to transcriptional regulators and a brand new type of regulatory components, the riboswitch.

The quantity extra offers with the metabolic engineering of microorganisms for the biotechnological creation of amino acids to be used as prescribed drugs and, quite, as foodstuff and feed ingredients. accomplished studies are given of contemporary achievements to permit or increase creation of amino acids and dipeptides through fermentation and enzyme catalysis. the following, the actual concentration is on metabolic engineering, the rational development of metabolic services utilizing recombinant DNA technology.

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Extra resources for Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering

Example text

40 2 Lysine Biosynthetic Pathways . . . . . . . . . . . . . 3 Corynebacterium glutamicum as a Production Organism Lysine Biosynthesis . . . . . . . . . . . Central Carbon Metabolism . . . . . . . . Maximal Lysine Production Capacity . . . . . . . . . . . . 5 Strain Engineering . . . . . . . . . . . . . . . Classical Engineering . . . . . . . . . . . . . . Metabolic Engineering of Lysine Biosynthesis .

62 . . . . . . . . . . . . . . Abstract l-lysine is an essential amino acid required for nutrition of animals and humans. It has to be present in food and feed, which, in many cases, is realized by supplementation of the feed-stuffs with pure lysine. The high importance of lysine in nutrition has stimulated intensive research on the lysine biosynthetic pathways and their regulation and the search for microorganisms capable of over-producing this amino acid. As an important milestone, the glutamate producing soil bacterium Corynebacterium glutamicum was isolated in 1956 and soon received interest to be used for production of another amino acid stemming from the TCA cycle: lysine.

62 . . . . . . . . . . . . . . Abstract l-lysine is an essential amino acid required for nutrition of animals and humans. It has to be present in food and feed, which, in many cases, is realized by supplementation of the feed-stuffs with pure lysine. The high importance of lysine in nutrition has stimulated intensive research on the lysine biosynthetic pathways and their regulation and the search for microorganisms capable of over-producing this amino acid.

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Amino Acid Biosynthesis ~ Pathways, Regulation and Metabolic Engineering by Hiroshi Shimizu, Takashi Hirasawa (auth.), Volker F. Wendisch (eds.)


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