By Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)
Acute Myelogenous Leukemia is a well timed compilation of latest options within the molecular pathogenesis and molecular treatment of acute myelogenous leukemia (AML). the point of interest is on chosen severe molecular determinants of AML pathogenesis and pathophysiology and the exploitation of those elements through varied healing brokers and modalities. Bringing jointly new ideas and findings within the uncomplicated and medical technological know-how of AML, the e-book emphasizes the molecular foundation for brand new treatments that stand to have the best capability impression at the scientific face of those ailments. The textual content offers insights into chosen novel thoughts at present and prospectively being constructed, together with interruption of particular sign transduction pathways, modulation of gene expression, makes an attempt to reinstate differentiation, and immunomodulation. there's an emphasis all through at the bidirectional circulation of information among the medical and laboratory arenas, and either simple and medical scientists will reap the benefits of this translational textual content.
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Additional resources for Acute Myelogenous Leukemia
Friedman AD. Leukemogenesis by CBF oncoproteins. Leukemia 1999;13:1932-1942. 7. Okuda T, van Deursen J, Hiebert SW, Grosveld G, Downing JR. AML-l, the target of multiple chromosomal translocations in human leukemia, is essential for normal murine fetal hematopoiesis. Cell 1996;84:321-330. 8. Wang Q, Stacy T, Binder M, Marin-Padilla M, Sharpe AH, Speck NA. Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis. Proc Nat! Acad Sci USA 1996;93:3444-3449.
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Chapter 1 I AML Treatment: Biological Perspective 23 185. Kang CD, Yoo SD, Hwang BW, et al. The inhibition of ERKIMAPK not the activation of JNK/SAPK is primarily required to induce apoptosis in chronic myelogenous leukemic K562 cells. Leuk Res 2000;24: 527-534. 186. Kim SC, Hahn JS, Min YH, Yoo NC, Ko YW, Lee Wl Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1.
Acute Myelogenous Leukemia by Farhad Ravandi, Francis Giles (auth.), Judith E. Karp MD (eds.)