Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins PDF

By Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)

ISBN-10: 1461290643

ISBN-13: 9781461290643

ISBN-10: 1461319137

ISBN-13: 9781461319139

The manuscripts during this quantity have been contributed via the audio system invited to the Acromegaly Centennial Symposium held in San Francisco, California in July 1986. The assembly used to be prepared to commemorate the outline of acromegaly by way of the French health practitioner Pierre Marie, in 1886. The individuals of the medical Committee spent many hours supporting us in making sure an excellent assembly. The aid of Serono Symposia, united states in all stages of the making plans and execution of the assembly was once basically preferred and was once hugely specialist. distinct popularity roust be prolonged to Professor Roger Guillemin of the Salk Institute, whosp curiosity in clinical background led him to commit loads of time and private cost in acquiring information regarding the lifetime of Pierre Marie. Dr. GuilIemin's presentation at the lifestyles and instances of Marie was once a unprecedented evaluate of the cultural, social, and clinical backgrounds during which Marie got here to explain the disorder, acromegaly. Dr. Guillemin' s findings, which have been offered on the major ceremonial dinner in a most appropriate audiovisual presentation, have been essentially the spotlight of the assembly and should lengthy be remembered via the attendees. We have been additionally commemorated through the presence of Dr. Martine Pierre Marie Granier, the great-granddaughter of Pierre Harie. In her tackle on the dinner party, Dr. Granier supplied numerous pleasant and intimate vignettes touching on Pierre Marie, utilizing previous family members documents and pictures. The clinical Committee needs to increase its gratitude to Dr. Granier for including immeasurably to the historic surroundings of the meeting.

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Additional resources for Acromegaly: A Century of Scientific and Clinical Progress

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Yalow RS. Heterogeneity of peptide hormones. Recent Prog Horm Res 1974; 30:597. Diamond RD, Wartofsky L, Rosen SW. Heterogeneity of circulating growth hormone in acromegaly. J Clin Endocrinol Metab 1974; 39:1133. Wright DR, Goodman AD, Trimble KD. Studies on "big" growth hormone from human plasma and pituitary. J Clin Invest 1974; 54:1064. Talamantes F, Lopez J, Lewis UJ, et a1. Multiple forms of growth hormone: detection in medium from cultured pituitary adenoma explants. Acta Endocrinol (Copenh) 1981; 98:8.

Evidence for another diabetogenic 31 substance also comes from the report by Hart et al. (40) who showed that a preparation of bovine GH with the greatest growth promoting activity was not the most diabetogenic fraction isolated from the pituitary. Another pituitary fraction rich in low molecular weight substances showed the greatest diabetogenic activity. At this time there is no clear explanation for the multiple forms of GH. The assumption has been that since the newly recognized forms of GH are found in the pituitary gland only in small quantities, they must be of minor importance.

Human growth hormone. New York: Plenum Publishing Corporation, 1986. Kostyo JL, Cameron CM, Olson KC, Jones AJS, Pai R-C. Biosynthetic 20-kilodalton methionyl-human growth hormone has diabetogenic and insulin-like activities. Proc Nat Acad Sci USA 1986; 82:4250. Smal J, Closset J, Hennen G, de Meyts P. Receptor binding and insulin-like effects of 22K human growth hormone and its 20K variant in the rat adipocytes. Endocrinology 1986; 118(suppl):122. Schwartz J, Foster CM. Pituitary and recombinant deoxyribonucleic acid-derived human growth hormones alter glucose metabolism in 3T3 adipocytes.

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Acromegaly: A Century of Scientific and Clinical Progress by Dr. Martin Pierre Marie Granier (auth.), Richard J. Robbins M.D., Shlomo Melmed M.D. (eds.)


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